MICROSCOPY WHITE PAPERS AND CASE STUDIES

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“Fingerprint” Vs Handheld Raman Applications And The Different Optical Filters That Enable Them
Raman spectroscopy is a powerful analytical tool capable of identifying molecular constituents of samples under test. When combined with microscopy, it can also be used as a non-invasive, non-contact solution for exploring specific cellular structures and functions. It is no wonder that Raman has established a presence as an invaluable analytical technique both in labs and in the field.   Continue Reading..
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Creating Tungsten Tips Using Mad City Labs SPM Etch Kit
he Mad City Labs SPM etch kit is designed allow users to create a sharp tungsten tip suitable for scanning probe microscopy. The instrumentation allows the user to attach a tungsten wire to a quartz tuning fork and electrochemically etch the wire. This application note describes the process of creating tungsten tips using the SPM etch kit.  Continue Reading..
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AFM With Manual XY And Automated Z Approach And Camera
An atomic force microscope (AFM) can be built using Mad City Labs products along with other off-the-shelf components. This application note describes the construction of an AFM automated Z approach with the addition of a camera with a coaxial illuminator to view the tip approach.  Continue Reading..
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Understanding Virus Mechanisms — One Particle At A Time
Single-molecule microscopy techniques facilitate direct study of molecular mechanisms, enabling leaps in understanding surrounding how viruses assemble, disassemble, and interact with their hosts.  Continue Reading..
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Utilizing Fluorescence Filters For Microscopy And Imaging
Fluorescence microscopes and imaging systems utilize fluorescent biomarkers and fluorescence filter sets to create bright, high contrast images of biomolecules, organelles, cells, tissues, organs, and organ systems. Because image quality is highly dependent on the design and overall performance of the fluorescence filters integrated into these systems, optical filter performance is just as important to the final image as sample preparation and...  Continue Reading..
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PentaVac™ Vacuum Technology: Scientific CCD Applications
CCD imaging sensors are used extensively in high-end imaging applications, enabling acquisition of quantitative images with both high (spatial) resolution and high sensitivity. There are some photon-starved applications which require even these highly sensitive devices to be used with both long integration (exposure) times and high amounts of binning (on-chip charge summation) in order to obtain a detectable signal. For these type of...  Continue Reading..
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Near-Field Scanning Optical Microscopes: Capabilities And Applications
NSOM techniques and instrumentation have evolved to become vital tools for material characterization, providing high-quality data and continually expanding utility.  Continue Reading..

MICROSCOPY PRODUCTS

The MCL-NSOM is a near field scanning optical microscope using a resonant probe. The MCL-NSOM is built on a microscope platform with access to optical pathways making it ideal to use with optical microscopy techniques. The MCL-NSOM includes 6 axes of motorized positioning and 3 axes of closed loop nanopositioning for exceptional position resolution. The NSOM can be operated in 5 standard NSOM modes and can also be used solely as a resonant probe AFM.

The SPM-M kit is a do-it-yourself atomic force microscope (AFM). The SPM-M kit produces a high performance, resonant probe AFM suitable for both research and teaching environments. It includes the MadPLL® controller, 3 axes of closed loop nanopositioning, resonant probes and AFMView™2 software. A wide range of AFM accessories are also available.

The Nano-LPQ Series offers ultra-low profile 3-axis nanopositioning systems designed for high speed microscopy applications. The Nano-LPQ is designed with an integrated slide holder and incorporates proprietary PicoQ sensors which yield low noise performance under closed loop control.

The MicroMirror TIRF microscope is a unique single molecule microscope. Spatial separation of the excitation and emission beams and the use of broadband micromirrors leads to superior signal-to-noise ratios for multi-wavelength TIRF microscopy. The open access to the excitation and emission optical pathways makes this the ideal platform to implement a range of biophysical techniques simultaneously. 

The Nano-LPS Series comprises ultra-low profile 3 axis nanopositioning systems with sub-nanometer precision under closed loop control. Designed for single molecule microscopy, super resolution microscopy, and nanoscopy applications, the Nano-LPS incorporates the exclusive PicoQ sensor technology which ensures high stability and low noise performance.  The Nano-LPS is ideal for researchers seeking to add nanometer precision to their microscopy research.

Need to integrate laser beam measurements in a system? Gentec-EO can make it happen thanks to a broad range of custom solutions. All products can be customized to meet specific requirements and they can all be used as original equipment manufacturing.

The steep edges, maximum transmission, and maximum reflection of ULTRA Series thin-film dichroic filters all translate into minimal loss of light intensity and optimal instrument performance. Each ULTRA Series dichroic filter, polychroic filter, dichroic beamsplitter, or beam combiner is resistant to laser damage and can be designed to work at any angle. All are ideal for use in applications such as fluorescence microscopy, flow cytometry, and Raman spectroscopy.

The deep blocking, tight wavelength control, steep edges, and wide-range transmission of ULTRA Series thin-film notch filters all allow for precision blocking of lasers or other light sources, without sacrificing the quality of target signals.

Each hard-coated ULTRA Series optical notch filter is designed and rigorously tested to exceed the most advanced system requirements. They are all ideal for use in applications such as fluorescence microscopy, endoscopy, and DNA sequencing.

MICROSCOPY SUPPLIERS

BaySpec, Inc., founded in 1999 with 100% manufacturing in the USA (San Jose, California), is a vertically integrated spectral sensing company. The company designs, manufactures and markets advanced spectral instruments, including UV-VIS-NIR-SWIR spectrometers, benchtop and portable NIR/SWIR and Raman analyzers, confocal Raman microscopes, hyperspectral imagers, mass spectrometers, and OEM spectral engines and components, for the R&D, biomedical, pharmaceuticals, chemical, food, semiconductor, health monitoring, human & animal medical devices, and the optical telecommunications industries.

Canon U.S.A., Inc., is a leading provider of business-to-business, industrial and consumer digital and optical imaging solutions to the United States, Latin America and the Caribbean (excluding Mexico) markets with an increasing intent for more customized, localized products.

Infrared Cameras|Infrared Imaging Subsystems|Thermal Cameras|Infrared Camera Subsystems|Ruggedized Infrared Cameras|Visual Inspection, Thermal|Infrared Surveillance|Video Inspection Systems, Thermal|Infrared Detectors|Thermal Sensors|Night Vision Cameras|Night Vision Systems|Detectors, Infrared|Detectors, Heat|Infrared Imagers|Infrared Equipment|Infrared Sensors|Security Systems, Infrared|Thermal Imaging Systems|Military Infrared Sensors|Integrated Detective Assemblies, Infrared|Optical Inspection Systems,Thermal|Thermal Camera Systems|Night Vision Components|Infrared Video Cameras|Data Acquisition Software,Infrared|Focal Plane Arrays|Machine Vision Systems, Infrared|Infrared Industrial Detectors|Infrared Inspection Systems|Automated Inspection, Infrared

Gooch & Housego provides complete optical system design, engineering and manufacturing services to the aerospace & defense, industrial, life sciences and scientific research sectors, based upon the following key enabling photonic technologies: Acousto-Optics, Crystal Optics Electro-Optics, Fiber Optics and photonic packaging, Non-Linear Optics, Precision Optics including optical polishing and coatings, as well as light measurement instrumentation and services, spectral Imaging & synthesis.

Photomultiplier Tubes|Arc Lamp|Photo Multiplier|Spectroscopy Systems

Iridian Spectral Technologies is a diversified optical filter manufacturer that is an international leader in filter design and manufacture especially for application in the fields of fiber optic communications, optical spectroscopy, 3D entertainment, and in aerospace. Iridian Spectral Technologies was ranked as one of the top 150 high technology companies in Canada in the 2011 and 2012 Branham300 rankings and won the 2010 Canada Export Achievement Award for the province of Ontario sponsored by Profit magazine together with Export Development Corporation (EDC). Iridian Spectral Technologies is a global supplier with distributors in many countries particularly in Asia.

Mad City Labs, Inc. is the leading US manufacturer of precision piezo based nanopositioning stages and nano-instrumenation.  We manufacture high performance motion control instrumentation including our innovative closed loop nanopositioning systems, high stability microscopy platforms, low cost probe microscopy and metrology solutions.  Our instruments are suitable for super resolution microscopy, metrology, imaging, photonics, interferometry and astronomy.

PCO-TECH Inc., founded in 1986, is a manufacturing, sales and marketing organization offering photonic instrumentation and complete systems throughout the world

Photron was founded in 1974 to provide manufacturing, sales and service of professional film and video equipment and photo-instrumentation

PI (Physik Instrumente) provides the world’s broadest range of precision motion technologies for both micro- and nano-precision applications. PI is the world’s first and largest manufacturer of piezoelectric nanopositioning technology.  Started 4 decades ago as a supplier to research labs and universities, the company has grown into a business of 700+ employees and more than $100 million in global sales.

For over 30 years, Precision Optics Corporation has provided state-of-the-art optical designs, components and complete optical systems for medical, biomedical, military (ITAR complainant) and industrial applications. As next generation techniques in these areas have advanced to use smaller and less invasive tools and equipment, Precision Optics responded with microprecision™ optical technology to provide components, assemblies, and products with sizes on the order of one millimeter and smaller.

Raptor Photonics Limited is a global leader and manufacturer of high performance, industrial-grade and extremely rugged ultra-low light digital and analogue cameras.

UTC Aerospace Systems (Sensors Unlimited Products), is the world’s leading manufacturer of indium gallium arsenide (InGaAs)-based imaging products. As renowned experts in shortwave infrared (SWIR) imaging, Sensors Unlimited, Inc. introduced the world to the concept of imaging in the shortwave IR spectrum with simple, compact, and uncooled cameras.

Xenics is a well established and rapidly growing high-tech company about to enter exciting new fields of IR products and applications, serving the markets with excellent products and a strong technology background.

Supplier of precision optics including extreme precision aspheres and freeform, meter-class flats and windows in common and exotic materials. Full electro-mechanical-optical design/prototype and manufacturing capabilities for medical, defense, military, ISR, semiconductor and industrial technology research.

MICROSCOPY NEWS

  • An Electrical Trigger Fires Single, Identical Photons

    Secure telecommunications networks and rapid information processing make much of modern life possible. To provide more secure, faster, and higher-performance information sharing than is currently possible, scientists and engineers are designing next-generation devices that harness the rules of quantum physics.

  • Getting A Grip On Near-Field Light

    There are many types of light — some visible and some invisible to the human eye. For example, our eyes and brain don’t have the tools to process ultraviolet light when it hits our eyes, making it invisible.

  • Tiny Bubbles Make A Quantum Leap

    Researchers at Columbia Engineering and Montana State University report today that they have found that placing sufficient strain in a 2D material—tungsten diselenide (WSe2)—creates localized states that can yield single-photon emitters.

  • Excelitas To Highlight Fluorescence Illumination Solutions For Microscopy At Biophysical Society 2019

    Excelitas Technologies Corp., a global technology leader delivering innovative, customized photonic solutions, will showcase its broad offering of X-Cite fluorescence illumination products for microscopy and debut its new white light LED light source at the 63rd Annual Meeting of the Biophysical Society.

  • New Ophir® PD300-MS Power Meter For Fluorescence Microscopy Measures High NA Microscope Objectives

    MKS Instruments, Inc., a global provider of technologies that enable advanced processes and improve productivity, has announced the Ophir® PD300-MS microscope slide power meter for accurate measurements of light emitted from fluorescence microscopes. The PD300-MS measures power levels of high numerical aperture (NA) objectives, from 5µW to 1W. A special filter provides low angular dependence, enabling higher accuracy measurements. NIST-traceable calibration allows for measurement of wavelengths from 350nm to 1100nm. The power meter is designed for use with a wide range of light sources in such applications as photoactivation or photobleaching. To accommodate limited space, it has the same footprint as a standard microscope slide. The PD300-MS can be used at the sample plane in air or with water/oil immersion objectives without damage.

  • Powerful New Imaging Method Reveals In Detail How Particles Move In Solution

    New research published in Nature Methods will dramatically improve how scientists “see inside” molecular structures in solution, allowing for much more precise ways to image data in various fields, from astronomy to drug discovery.

  • Rice Team Designs Lens-Free Fluorescent Microscope

    Lenses are no longer necessary for some microscopes, according to Rice University engineers developing FlatScope, a thin fluorescent microscope whose abilities promise to surpass those of old-school devices.

  • Super-Resolution Microscopy In Both Space And Time

    In a breakthrough for biological imaging, EPFL scientists have developed the first microscope platform that can perform super-resolution spatial and temporal imaging, capturing unprecedented views inside living cells. The landmark paper is published in Nature Photonics.

  • Leti Develops Lens-Free, Point-Of-Care System For Diagnosing Spinal Meningitis

    Leti, a research institute at CEA Tech, has invented a lens-free microscope technology that provides point-of-care diagnosis for spinal meningitis. Outlined in a paper presented at Photonics West, the new technology provides immediate results and eliminates errors in counting white blood cells (leukocytes) in cerebrospinal fluid, which is required to diagnose the infection.

  • Researchers Achieve Resolutions In The 30 Nanometre Range

    Objects smaller than half the wavelength of the utilised light cannot be viewed with the aid of traditional light microscopes. A research team from Ruhr-Universität Bochum (RUB) and the University of Basel has succeeded in enhancing the resolution for microscopic analysis of solid state systems to 1/31 of the wavelength of the utilised light.

  • Magnetic Fields Of Bacterial Cells, Nano-Objects Mapped Using Electron Microscopy

    A research team led by a scientist from the U.S. Department of Energy’s Ames Laboratory has demonstrated for the first time that the magnetic fields of bacterial cells and magnetic nano-objects in liquid can be studied at high resolution using electron microscopy.

  • Hollow Optical Antennas For Superior Photon Creation And Control

    Scientists at Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany, have introduced a novel plasmonic cavity antenna design that enhances the creation and control of photons emitted by atoms and molecules.

  • Novel Lenses Enable X-Ray Microscopy With Record Resolution

    Scientists have developed novel lenses that enable X-ray microscopy with record resolution in the nanometre regime. Using new materials, the research team led by DESY scientist Saša Bajt from the Center for Free-Electron Laser Science (CFEL) has perfected the design of specialised X-ray optics and achieved a focus spot size with a diameter of less than ten nanometres.

  • Ultraviolet Microscope To Dramatically Speed Up Lab Tests

    A microscope using ultraviolet (UV) light to provide high-resolution histological images promises to significantly shorten the amount of time diagnostic tests are processed.

MICROSCOPY VIDEOS