Mad City Labs, Inc is a leading manufacturer of flexure based nanopositioning systems capable of sub-nanometer positioning resolution. Our product line covers the entire spectrum of nanopositioning capabilities while maintaining a leadership role in multi-axis stages for high speed optical microscopy imaging. Mad City Labs design engineers use 3D CAD and finite element analysis to produce nanopositioners which combine long ranges of motion with exceptional linearity, orthogonality, and stability. Our in-house CNC machining centers provide complete control of mechanical assembly production and allow Mad City Labs to design and fabricate custom systems with minimal engineering costs and short lead times. We deliver the tools for nanotechnology in 30 to 45 days and provide the highest level of customer service and satisfaction in the industry. We provide innovative and practical solutions for today’s demanding biotechnology and nanotechnology applications. Applications for nanopositioners include super resolution microscopy, high speed confocal imaging, AFM, NSOM, scanning probe microscopy, fiber positioning, single molecule spectroscopy, single molecule/particle tracking, high resolution optical alignment, SR optical microscopy, sub-diffraction limit microscopy, nanoscopy and lithography.


Near-Field Scanning Optical Microscope: MCL-NSOM
Near-Field Scanning Optical Microscope: MCL-NSOM
The MCL-NSOM is a fully operational near-field scanning optical microscope manufactured on Mad City Labs’ versatile RM21™ inverted optical microscope. This instrument is designed to allow users to convert between NSOM, SPM, and fluorescence optical microscopy techniques.  Continue Reading..
RM21™ Microscope For Fluorescence Microscopy
Microscope For Fluorescence Microscopy
Mad City Labs’ RM21 Microscope is a microscopy platform designed to allow direct access to the entire optical pathway, and is capable of precision alignment in the X, Y, and Z axes. The Z-axis objective lens holder is aligned with the platform's optical axis and can hold a single objective lens.   Continue Reading..
XYZ Nanopositioning System: Nano-LPMW
XYZ Nanopositioning System: Nano-LPMW
The Nano-LPMW is a unique XYZ axis nanopositioning system designed to hold multiwall plates, slides, dishes, and environmental chambers. This low profile positioner has an extra-large center aperture with a 200 micron range of motion on all three axes. It is easily integrated into existing inverted optical microscopes and is compatible with numerous microscope stages.  Continue Reading..
Mad City Labs Custom Solutions And OEM Partnerships
Mad City Labs Custom Solutions And OEM Partnerships
Mad City Labs offers a broad range of custom solutions able to meet specialized requirements ranging from simple modifications of existing designs to completely custom projects. Customers can move easily from project concept to reality with in-house research scientists’ extensive knowledge of UHV instrumentation, optical spectroscopy, and nanotechnology. Mad City labs also develops custom firmware and dll’s to speed up final product...  Continue Reading..
MicroMirror TIRF System
MicroMirror TIRF System
Mad City Labs' MicroMirror TIRF system is a new single molecule imaging instrument composed with high precision, high stability nanopositioning and microscopy technologies. It is designed for studying the ordered assembly and function of multi-component biomolecular machines.  Continue Reading..
Precision Nanopositioning Systems: Nano-HS Series
Precision Nanopositioning Systems: Nano-HS Series
The Nano-HS Series is a multi-axis, high speed, precision Nanopositioning system made up of two models, Nano-HS2 and Nano-HS3, offering picrometer positioning resolution, and XY or XYZ motion with maximum versatility. The Nano-HS Series utilizes PicoQ® Technology through its internal positioning sensors in order to provide absolute, repeatable position measurement under closed loop control.  Continue Reading..
Three Axis Nanopositioning Systems: Nano-LPS Series
Three Axis Nanopositioning Systems: Nano-LPS Series
Mad City Labs’ Nano-LPS Series of three-axis nanopositioning systems is comprised of three separate models with 100, 200, and 300 micron ranges of motion. Their low height makes them ideally suited for integration in inverted optical microscopes. Each model in the series is well-suited for handling biological samples due to an aperture that’s able to accommodate full size (3 inch) slides.  Continue Reading..
Heavy Duty Nanopositioners: Nano-HL Series
These nanopositioners have been designed to carry heavy optics or sensor assemblies weighing up to 10kg and have enough physical rigidity to counteract large off-axis loads with high positional stability and precise positioning. Additional features include single axis motion, and 50, 100, and 200µm motion ranges.  Continue Reading..
High-Speed, Direct Drive Nanopositioners: Nano-OP Series
This family of high-speed nanopositioners is comprised of three separate models with 30, 60, and 100µm ranges of motion. They can be configured into a wide variety of applications involving interferometry, nanomanipulation, high-speed lens focusing, fiber optics, and NSOM.  Continue Reading..
Piezoelectric Mirror Tip/Tilt Actuators: Nano-MTA Series
Piezoelectric Mirror Tip/Tilt Actuators: Nano-MTA Series
The Nano-MTA series is comprised of single and two axis piezoelectric mirror tip/tilt actuators with nanoradian resolution, making them ideal for applications involving high speed laser beam steering, optical disk manufacturing, interferometry, optical trapping, FBG writing, astronomy, and active optics.  Continue Reading..
Three-Axis Compact Nanopositioners: Nano 3D Series
Three-Axis Compact Nanopositioners: Nano 3D Series
The Nano-3D200 and Nano-3D500 are compact nanopositioners used for optical fiber alignment and hybrid positioning systems. Both models feature a compact size, three-axis motion, closed loop control, and true flexure guided motion.  Continue Reading..
SPM-M Kit For Scanning Probe Microscopy
SPM-M Kit For Scanning Probe Microscopy
Scanning probe microscopy is an imaging technique typically used for industrial wear testing, semiconductor manufacturing, or academic research applications. While it can yield high-resolution imagery, SPM systems can be rather expensive and take skill to build. Mad City Labs' SPM-M kit has been designed to allow operators to build a tuning fork, Akiyama probe, AFM (atomic force microscope), or a scanning resonant probe microscope to capture...  Continue Reading..
High Precision Nanopositioning Systems: Nano-MET Series
High Precision Nanopositioning Systems: Nano-MET Series
The Nano-MET series of nanopositioning systems have been designed to provide picometer positioning resolution for metrology, AFM, and SPM applications. Three models are available in the series with variations in configuration, size, noise floor, response time, and more.  Continue Reading..
Nanopositioner Focusing Elements: Nano-F Series
Nanopositioner Focusing Elements: Nano-F Series
The Nano-F Series by Mad City Labs are nanopositioner focusing elements for applications involving confocal imaging, auto focusing, STORM imaging, and PALM imaging. They offer 100 or 200 microns of travel and are operable as standalone focusing elements or with other Mad City Labs’ nanopositioning stages.  Continue Reading..
High Precision Positioning: MMP Series
High Precision Positioning: MMP Series
Mad City Labs’ MMP series of positioners have a 25mm range of motion and are available in 1, 2, or 3-axis configurations. They feature optical encoders with 50nm resolution, proprietary intelligent control for stability, nanopositioner compatibility, and high native precision and accuracy.  Continue Reading..


Mad City Labs, Inc.

2524 Todd Drive

Madison, WI 53713


Phone: 608 298-0855


  • New Mad360™: Precision Rotational Positioning System

    The Mad360™ is a compact precision rotational stage. The rotational motion is bidirectional and continuous 360°. Minimum rotational steps of 1 milliradian and capable of speeds up to 20 rotations/second, the Mad360™ is a versatile motion control device.

  • Versatile, High Precision Near Field Scanning Optical Microscope

    Mad City Labs recently announced the release of the MCL-NSOM, a versatile near-field scanning optical microscope (NSOM). The MCL-NSOM is an aperture NSOM built on Mad City Labs RM21™ inverted optical microscope, which allows users to convert to aperture-less NSOM, AFM and fluorescence optical microscopy.


  • Near-Field Scanning Optical Microscopes: Capabilities And Applications

    NSOM techniques and instrumentation have evolved to become vital tools for material characterization, providing high-quality data and continually expanding utility.

  • Resonant Probe AFM: Uses And Advantages

    Resonant probe atomic force microscopes’ unique construction and functionality enable them to serve in applications demanding spot-on accuracy, adaptability, and exceptionally high definition.

  • SPM-M Kit For Scanning Probe Microscopy Brochure

    SPM-M Kit is designed to allow operators to build a tuning fork, Akiyama probe, AFM (atomic force microscope), or a scanning resonant probe microscope to capture high resolution imagery in both commercial and R&D applications. The kit includes a Nano-SPM200 nano-positioning stage (XY), a Nano-OP30 nano-positioning stage (Z), and a 3 axis closed loop Nano-Drive® controller, but it may also be customized by substituting any nano-positioners and pico-positioners and many additional options.

  • Extreme Metrology: Big Science Requires A Nano-Perspective

    Extreme metrology applications involve more than enough unknown variables. Instrumentation whose performance has been proven should not be one of them.

  • How To Specify A Custom-Designed Instrument

    Customers with a clear-eyed view of the solution’s basic specifications, budget, and expected timeline are well-positioned for an efficient, effective custom design experience.

  • Is A DIY Microscope For You?

    Whether modifying existing instrumentation or building a new tool from the ground up, a meticulous process is as critical as the functional result.

  • Custom Vs. Off-the-Shelf Solutions: Are You Dreaming Big Enough?

    Custom positioning solutions provide more leeway for innovation, and at far less cost, than many customers realize.

  • Close Is Not Close Enough: Micropositioners’ Role In Nanopositioning

    This article examines how micropositioners affect movement and positioning capability, as well as overall task effectiveness, by creating --literally -- a solid foundation for work at the nanoscale.

  • Optical Micromirrors Reveal The Secrets Of Cell Membranes

    Progress in understanding the lipid bilayer – a two-molecule thick oily barrier that protects all living cells – has been dramatic over the past 100 years. But puzzles remain to be solved, such as how these membrane proteins navigate the oily lipid bilayer to go about their work. 

  • Poking And Prodding The Molecules Of Life

    Applying physics to the properties and underlying structures of the molecules of life offers an insight into the mechanisms that make living beings tick. But even seemingly simple actions like muscle contraction involve a wide array of biological interactions.