The Mad360™ is a compact precision rotational stage. The rotational motion is bidirectional and continuous 360°. Minimum rotational steps of 1 milliradian and capable of speeds up to 20 rotations/second, the Mad360™ is a versatile motion control device.

Mad City Labs recently announced the release of the MCL-NSOM, a versatile near-field scanning optical microscope (NSOM). The MCL-NSOM is an aperture NSOM built on Mad City Labs RM21™ inverted optical microscope, which allows users to convert to aperture-less NSOM, AFM and fluorescence optical microscopy.

Customers with a clear-eyed view of the solution’s basic specifications, budget, and expected timeline are well-positioned for an efficient, effective custom design experience.

Whether modifying existing instrumentation or building a new tool from the ground up, a meticulous process is as critical as the functional result.

Custom positioning solutions provide more leeway for innovation, and at far less cost, than many customers realize.

This article examines how micropositioners affect movement and positioning capability, as well as overall task effectiveness, by creating --literally -- a solid foundation for work at the nanoscale.

Progress in understanding the lipid bilayer – a two-molecule thick oily barrier that protects all living cells – has been dramatic over the past 100 years. But puzzles remain to be solved, such as how these membrane proteins navigate the oily lipid bilayer to go about their work. 

Applying physics to the properties and underlying structures of the molecules of life offers an insight into the mechanisms that make living beings tick. But even seemingly simple actions like muscle contraction involve a wide array of biological interactions. 

Every nanopositioner has a small amount of uncertainty in its position that contributes noise to a measurement. It's important to understand what position noise is and where it comes from in order to know just how accurate the nanopositioner is.

Total internal reflection fluorescence (TIRF) microscopy is used to watch biological processes unfold in real time. Taking advantage of the ability to label individual molecules with different colors of fluorescent tags, TIRF microscopy lets scientists view the complex molecular assemblies that govern cellular processes.

Atomic force microscopes (AFMs) are versatile tools for characterizing surfaces down to the subnanometer scale. Researchers can build their own AFMs for as little as $30,000 using off-the-shelf components such as nanopositioning stages.

The RM21™ Advanced Microscope is our most versatile inverted optical microscope capable of supporting super resolution microscopy, multi-spectral CoSMoS, and a variety of light microscopy methods. It is ideal for single molecule localization microscopy and epifluorescence microscopy but can be extended to other microscopy methods including optical and magnetic tweezers, and AFM integration.