Every nanopositioner has a small amount of uncertainty in its position that contributes noise to a measurement. It's important to understand what position noise is and where it comes from in order to know just how accurate the nanopositioner is.
Total internal reflection fluorescence (TIRF) microscopy is used to watch biological processes unfold in real time. Taking advantage of the ability to label individual molecules with different colors of fluorescent tags, TIRF microscopy lets scientists view the complex molecular assemblies that govern cellular processes.
Atomic force microscopes (AFMs) are versatile tools for characterizing surfaces down to the subnanometer scale. Researchers can build their own AFMs for as little as $30,000 using off-the-shelf components such as nanopositioning stages.
The RM21™ Advanced Microscope is our most versatile inverted optical microscope capable of supporting super resolution microscopy, multi-spectral CoSMoS, and a variety of light microscopy methods. It is ideal for single molecule localization microscopy and epifluorescence microscopy but can be extended to other microscopy methods including optical and magnetic tweezers, and AFM integration.
The RM21™ Classic Microscope is an inverted optical microscope that has been specifically designed for nanometer scale microscopy. It is ideal for single molecule localization microscopy and epifluorescence microscopy but can be extended to other microscopy methods.
The RM21™ Versa Microscope is an inverted optical microscope with a fixed objective lens position for maximum stability. It includes a sub-nanometer precision, Z-axis closed loop piezo nanopositioning system designed to meet the requirements of super resolution microscopy. The RM21™ Versa microscope is ideal for single molecule localization microscopy and epifluorescence microscopy where sub-nanometer precision is only required in the Z-axis.
The MCL-NSOM is a fully operational near-field scanning optical microscope that features a 635 nm laser excitation source, fiber launch, an oil immersion objective lens, a CMOS alignment camera, and an avalanche photodiode detector. It is designed to allow users to convert between NSOM, SPM, and fluorescence optical microscopy techniques.
The RM21™ Microscope is an adaptable microscopy platform that is designed to allow direct access to the entire optical pathway. The RM21™ is compatible with 30 mm and 60 mm cage systems, and is designed to be configured on a standing optical table. It is suitable for applications such as optical and magnetic tweezers, AFM integration and fluorescence microscopy.
The Nano-LPMW is designed to hold multiwall plates, slides, dishes, and environmental chambers. It is easily integrated into existing inverted optical microscopes and is compatible with numerous microscope stages. The Nano-LPMW is ideal for demanding microscopy applications which require long range travel, high stability, and three axes of motion.
The Nano-Drive Series of controllers are complete electronic packages for sub-nanometer positioning, featuring low noise, low drift amplifiers, absolute position control, bandwidth selection, and closed loop feedback. Mad City labs also develops custom firmware and dll’s to speed up final product development by incorporating special motion profiles into the OEM Nano-Drive® controller.
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