Spectroscopy White Papers and Case Studies
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Modular Raman Spectroscopy for Chemical Alcohol Discrimination
8/7/2012
Raman Spectroscopy provides convenient and rapid analysis for chemical sample identification, including alcohol and alcohol isomers. Its non-invasive measurement capabilities provide reliable and non-destructive testing in aqueous solutions, powders, gels, tablets, and surfaces. Additionally, there is no interference from water, and little to no sample preparation is required. This application note demonstrates how Ocean Optics modular Raman components differentiate between 10 different alcohol samples with similar molecular formulas.
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Diffuse Spectroscopy For Inhomogeneous Metal Nanoparticle Assays
7/13/2012
We describe a compact computational spectroscopy platform optimized for molecular recognition using metal nanoparticle assays. The objective is motivated by the urgent need for low-cost, portable and high-throughput sensors for point-of-care (POC) clinical diagnostics. Nanoparticle based sensing has been successfully demonstrated for diagnosis and monitoring of infectious diseases, drug discovery, proteomics, and biological agent detection. Molecular binding on the nanoparticle surface is transuded into an optical signal by modification of the nanoparticle extinction spectrum (via a shift in Localized Surface Plasmon Resonance) or by modification of the molecular scattering spectrum (via Surface Enhanced Raman Scattering). By Prasant Potuluri, Michael E. Sullivan, Yanqia Wang, David J. Brady, Centice
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Modular Spectroscopy Tools For The Simultaneous Measurement Of Fluorescein Absorbance And Fluorescence
6/25/2012
Spectroscopy is a powerful tool providing a wealth of information with the relatively simple measurement of how light interacts with a sample.
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High Performance Lasers for Raman Spectroscopy
6/4/2012
Raman Spectroscopy is a highly effective process used in materials analysis applications. Highly-collimated and monochromatic light sources are ideal for Raman Spectroscopy, making lasers the ideal light source for such a process. This application note discusses the benefits of using Cobolt’s DPSS (Diode Pumped Solid State) lasers as excitation sources in Raman Spectroscopy.
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Using Raman Spectroscopy To Detect Malignant Changes In Tissues
5/25/2012
Accurate, rapid, and non-invasive detection and diagnosis of malignant disease in tissues is an important goal of biomedical research. Optical methods, such as diffuse reflectance, fluorescence spectroscopy, and Raman spectroscopy, have all been investigated as ways to attain this goal. Diffuse reflectance utilizes the absorption and scattering properties of tissues, particularly from cell nuclei and stroma.
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Fluorescence Spectroscopy: A More Energy Efficient Light Source For Biomedial Research
5/18/2012
The measurement needs of fluorescence vary greatly depending upon the application. Avantes has worked closely with a number of researchers and process engineers to facilitate fluorescence measurements in research, clinical and industrial environments.
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Design Case Study: Fiber Optics Simplify Terahertz Imaging and Spectroscopy, Part II
3/16/2000
The second half of this article describes a T-ray system that integrates fiber-pigtailed modules and computer control in a compact, versatile instrument for terahertz time-domain spectroscopy and imaging.
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Design Case Study: Fiber Optics Simplify Terahertz Imaging and Spectroscopy, Part I
3/7/2000
The first half of this two-part article discusses the generation and detection of terahertz radiation for terahertz time-domain spectroscopy and imaging...