Next-Generation Fluorescence-Based Life Science Instrument

The prototype illustrated below represents a breakthrough in next-generation fluorescence-based life science instrumentation, combining advanced illumination, imaging, and system integration for unparalleled performance. At its core, a multi-wavelength LED and laser light engine provides high-brightness, multi-color illumination in a compact, fully integrated design. Customized beam shaping produces a uniform flat-top profile while a speckle reducer ensures consistent excitation, delivering outstanding power stability and long-term reliability.

Optimized fluorescence imaging is achieved with high-performance Semrock filters, enabling multi-color detection with exceptional sensitivity and spectral purity. Filters are custom-sized and shaped, with edge blackening tailored to any instrument configuration. Electromechanical integration leverages established partnerships for motion control, sensors, and cameras, complemented by in-house expertise in control electronics. A high-precision laser autofocus system with a fast piezo stage compensates for flow cell variations, allowing imaging on next-generation large-format cameras.

Full product qualification ensures reliability and performance, with end-to-end simulation, wavefront characterization at operating wavelengths, and dedicated testing stations to measure imaging quality and autofocus performance. Environmental and product reliability tests confirm robustness under demanding conditions.

Optomechanical design focuses on manufacturability, ultra-stable optical mounts, low-stress components, and effective stray light, thermal, and mechanical control. Custom objectives and tube lenses provide high numerical aperture, wide field-of-view, diffraction-limited resolution, minimal distortion, and consistent performance across spectral bands.

This compact, upgradeable system guarantees superior repeatability and performance, setting a new standard for fluorescence imaging in life science research and instrumentation development.