Polymorph And Ingredient Analysis With High-Resolution 1064 nm Dispersive Raman Spectroscopy

By Jack Qian, Lin Chandler, and William Yang

Polymorphism is crucial in the pharmaceutical industry because different polymorphs have different physical and chemical properties, such as chemical reactivity, solubility, stability, dissolution rate, and excipient compatibility in the formulation of medicines. Due to its importance, the screening of polymorph becomes necessary for drug research and development. In this application note, 1064 nm dispersive Raman is demonstrated as a viable, nondestructive method to identify polymorph and enable further component analysis on pharmaceutical tablets. Download the full paper for more information.