Novel, High-Linearity Atomic-Force-Spectrometer Apparatus For Quantitative Measurement

This poster analyzes a configuration of commercially-available single molecule force spectrometer that makes use of a faster and more linear actuator than previously possible. The linearity, bandwidth and comparative absence of hysteretic behavior for this multi-axis assembly ensure previously unattained resolution. Combined with a robust, simple, high-end design, this new generation of single molecule force-clamp instrumentation is ideally suited to capture the individual force-induced unfolding and folding trajectories of single protein molecules. Initial applications and results are reviewed. For more information, download the full poster.