Application Note

Lenses For Lightsheet Microscopy

The ExA-SPIM method revolutionizes microscopy by enabling visualization of centimeter-sized brain tissue with nanometer resolution, eliminating the need for tissue sectioning. This advancement is achieved through sophisticated tissue processing and cutting-edge fluorescence microscopy. Central to this innovation are our DIAMOND lenses, which boast a large image circle and high magnification, allowing for the analysis of larger samples in a single image without additional segmentation.

Pioneered by Adam Glaser and his team at the Allen Institute, this technique significantly enhances our understanding of brain structure and function, particularly in the study of complex neurological diseases and disorders. The ExA-SPIM microscope, leveraging these lenses, is poised to transform neuroscience by providing unprecedented insights into brain architecture and cellular organization.

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